Diabetes Drug Metformin Comes with Some Surprising Side-Effects: Here’s What you Need to Know

If you have diabetes and your doctor prescribes metformin, you need to know all the pros and cons of the medication. Read on to know just that.

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Written By: Jahnavi Sarma | Updated : March 23, 2021 1:22 PM IST

Type 2 diabetes is a metabolic disease that affects millions of people around the world. You are said to be diabetic when you have elevated blood sugar levels in your body. There is no cure for this condition. But medication and lifestyle changes can help you control your blood sugar levels. Metformin is the first-line therapy for patients who require oral medication to control type 2 diabetes. This drug belongs to a class of medications called biguanides. But this drug will not cure your diabetes, which is a metabolic condition, but it will definitely lower your blood sugar levels to a safe range. According to a study from Vanderbilt University Medical Center, the most common side effect of this medication is an upset stomach. But doctors can avoid this complication by titrating the dosage up slowly. But according to researchers of this study, it is not recommended for patients with kidney impairment. If you have diabetes and your doctor prescribes metformin, you have to take this drug for a long time. Hence, you need to be aware of some of the side effects that this drug can cause, both in the short as well as in the long run. But you need not panic. Both the mild as well as the serious side effects, which are the same in men and women, are treatable and will not cause any serious health complication provided you seek medical help and keep your doctor informed always.

Common and Mild Side Effects of Metformin

Many people experience the following side effects when they first start taking this drug. But the symptoms usually go away with time. But if the symptoms are severe, you need to consult your doctor. Heartburn, nausea, pain in the stomach, bloating and gas are common initially. Other digestive issues like diarrhea and constipation may also trouble you. You may experience some amount of weight loss. Some people also complain of a metallic taste in the mouth and recurring headaches.

What you Can Do to Ease These Symptoms

Try taking the drug along with food. This will help significantly. You can also ask your doctor to start you on a low dose and then increase the dosage gradually. It will help your body to adapt to the drug in a better way.

List of Serious Side Effects of Metformin

Metformin may not always cause serious adverse effects, but it is not unknown. Some people do experience severe reactions to this drug. Here we list a few of them.

Side Effect 1- Lactic acidosis

This is a very serious and severe side effect of metformin that requires emergency medical care. It happens because of a build-up of metformin in the body. The first obvious sign of lactic acidosis is trouble breathing. Other symptoms are fatigue, general weakness, a decrease in appetite, nausea, dizziness and a feeling of light-headedness. Your heart rate may become too fast or too slow and you may experience muscle pain and chills.

Side Effect 2 - Anaemia (Anemia)

You may become anaemic because this drug can lower the vitamin B-12 reserves in your body. This will make you tired and light-headed. You may also feel dizzy. But this does not mean that you stop taking your medication. Consult your doctor and follow his or her advice.

Side Effect 3 - Hypoglycemia

This is an exception and happens only if you take metformin along with other diabetic medications. A poor diet, heavy exercises and drinking may also trigger this side effect. Consult your doctor immediately if you experience abnormal heart-beat, nausea, weakness, stomach pain and fatigue.

Side Effect 4 - Dementia

Many studies have hinted at a link between metformin use and an increased risk of developing dementia. At the same time, other studies say that just the reverse is true. But what almost all agree on is that diabetes ups your risk of dementia significantly. This is irrespective of whether you use metformin or not.

Side Effect 5 - Nerve damage

As you know, metformin interferes with the absorption of vitamin B12 by the body. This can lead to a deficiency of this vitamin in your body thereby paving the way for nerve damage. But you need to know that uncontrolled diabetes too can cause nerve damage or neuropathy. So, it is difficult to say what really has caused the nerve damage, metformin use or uncontrolled diabetes.