Switch to हिंदी

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

हिंदी
  • Health A-Z
  • Home Remedies
  • Diseases
    • Type 1 Diabetes
    • Type 2 Diabetes
    • Cancer
    • Heart Attack
    • Pneumonia
    • Diseases A-Z
  • Diet & Fitness
    • Weight Management
    • Exercise & Body Building
    • Diet & Recipes
    • Yoga
  • Coronavirus
  • News
  • Pregnancy
    • Conceiving
    • Infertility
    • Labour & Delivery
    • Pregnancy week-by-week
    • Breastfeeding
    • Baby Names
  • Beauty
    • Skin
    • Hair
    • Grooming
  • Photos
  • Videos
Home / Diseases-conditions / Alzheimers / Asthma drug may help treat Alzheimer’s disease: Biogen’s antibody therapy awaits FDA approval

Asthma drug may help treat Alzheimer’s disease: Biogen’s antibody therapy awaits FDA approval

Asthma drug salbutamol helps prevent the formation of proteins associated with Alzheimer’s disease, reveals a new study.

By: Longjam Dineshwori   | | Updated: July 13, 2020 8:42 am
Tags: Alzeimer's disease  Alzheimer's treatment  
Alzheimer's disease
Alzheimer's is a type of dementia that affects memory, thinking and behaviour.

Around 50 million people are believed to be living with Alzheimer’s disease (AD)or other dementias worldwide. This number is more than the population of Columbia, according to the United Nations. Alzheimer’s disease is a neurological disorder that occurs when nerve cells in the brain die, resulting in memory loss and cognitive decline. Scientists have made some breakthroughs that could change the Alzheimer’s treatment landscape. Also Read - Beware! This could be an early sign of Alzheimer’s

A laboratory study, published in the journal ACS Chemical Neuroscience, has suggested that asthma drug salbutamol may help treat Alzheimer’s disease. The researchers at Lancaster University in the United Kingdom found that salbutamol help prevent the formation of proteins associated with the disease. Also Read - Identifying signs of Alzheimer’s even before symptoms set in possible



Asthma drug shows promise in AD treatment

The brains of Alzheimer’s patients have plaques (made of beta-amyloid protein) between the nerve cells and clumps of fibers called neurofibrillary tangles (made up of tau protein) inside the cells. As drugs that clear the beta-amyloid protein did not slow down the progression of the disease, the researchers shifted their attention to tau. Also Read - World Alzheimer's Day 2020: Misfolded proteins in the gut may be the culprit

They then tested the efficacy of 80 compounds in blocking the formation of the tau tangles. One of the compounds that show promising results was the hormone epinephrine, which helps stabilized tau proteins and successfully inhibited them from forming the tangles. However, since the body metabolizes epinephrine rapidly, the researchers started looking for drugs that have the same chemical structure as that of epinephrine and zeroed in on asthma drug salbutamol. Upon further testing, they found that salbutamol binds to tau molecules and prevents them from forming a nuclei, and hence reduces the possibility of other proteins to aggregate.

However, the researchers noted that their work is in the very early stages, and that further studies are needed to confirm whether or not salbutamol will be effective at treating Alzheimer’s disease in human patients. Further testing will be done on animal models of the disease, they added.

Will the FDA approve Biogen’s antibody therapy?  

Meanwhile, Biogen believes that its new antibody therapy could change the Alzheimer’s treatment landscape. The American multinational biotechnology company has completed the submission of a Biologics License Application (BLA) of its monoclonal antibody (mAb) aducanumab to the FDA for the treatment of Alzheimer’s disease. The drug, which helps clear amyloid plaques in the brain, is expected to be the first drug to reach the AD market.

However, some experts have expressed doubts about its approval from federal regulators due to a lack of substantial evidence about the efficacy of the drug. While one study showed convincing clinical efficacy with the high-dose arm, another study failed to show the same pattern of target engagement or clinical efficacy.

But key opinion leaders (KOLs) said that PDA is unlikely to turn down aducanumab even if its benefit is modest, as there is no therapy that is truly efficacious in Alzheimer’s treatment. The experts noted that no drug has been approved in the past 17 years in this disease area.

In March 2020, Biogen started a new multicenter safety study of aducanumab named EMBARK, including Alzheimer’s patients who had previously participated in the aducanumab studies. The trial was scheduled to be completed in Q3 2023 but it has been halted due to the Covid-19 pandemic.

Published : July 12, 2020 6:38 pm | Updated:July 13, 2020 8:42 am
Read Disclaimer

Get a flu shot if you want to bring down your risk of Alzheimer’s disease

Get a flu shot if you want to bring down your risk of Alzheimer’s disease

Negative thoughts can up your risk of Alzheimer’s disease: Counter this with a few lifestyle changes

Negative thoughts can up your risk of Alzheimer’s disease: Counter this with a few lifestyle changes

Please Wait. Article Loading ....

Coronavirus Updates

Coronavirus Updates

Stay Informed, Be Safe

  • This monoclonal antibody 'cocktail' may block COVID variants: Study
  • 85-year-old Dalai Lama gets first dose of COVID vaccine
  • Maharashtra records over 10,000 new coronavirus cases, highest since October
  • 101-year-old woman receives first dose of COVID-19 vaccine jab in Delhi
  • COVID-19 vaccine: Avoid taking these medicines before getting the jab

Health Calculators

BMI Calculator
bmi Calculator
Ideal Body Weight
ideal body weight
Daily Calorie Intake
Daily calorie intake
Calories Burned
calories burned

Related Stories

Beware! This could be an early sign of Alzheimer’s

Beware! This could be an early sign of Alzheimer’s

Identifying signs of Alzheimer’s even before symptoms set in possible

Identifying signs of Alzheimer’s even before symptoms set in possible

World Alzheimer's Day 2020: Misfolded proteins in the gut may be the culprit

World Alzheimer's Day 2020: Misfolded proteins in the gut may be the culprit

Get a flu shot if you want to bring down your risk of Alzheimer’s disease

Get a flu shot if you want to bring down your risk of Alzheimer’s disease

Health News in Hindi

Side Effects of Chicken: इंफर्टिलिटी का कारण बन सकता है चिकन का अधिक सेवन, इन अंगों को भी पहुंचाता है नुकसान

Sunflower Seeds Side Effects: सूरजमुखी के बीजों का अधिक सेवन किडनी को पहुंचाता है नुकसान, हो जाएंगी ये 6 समस्याएं

Diet Tips For Toddler: छोटे बच्‍चों को भूलकर भी न खिलाएं ये 5 फूड, वरना बच्‍चे को हो सकती है गंभीर समस्‍या

Healthy Diet: न्यूट्रिशनिस्ट रुजुता दिवेकर ने बताया दाल खाने का सही तरीका, कहा- दाल पकाने से पहले ध्‍यान रखें ये 3 बातें

तिब्‍बती धर्मगुरु दलाई लामा ने लगवाई कोविड वैक्सीन की पहली डोज, लोगों से भी टीका लगवाने का किया आग्रह

Read All

Recent Posts

  • Beware! Visual impairment may put you at higher risk of death
  • This monoclonal antibody ‘cocktail’ may block COVID variants: Study
  • Pincha Mayurasana: TV actress Aashka Goradia aces an advanced yoga pose, watch video here
  • BTS renews “Love Myself” campaign with UNICEF to end violence and promote self-esteem
  • Ladies, these ingredients will help you handle both worlds like a boss

About The health Site

TheHealthSite.com is India's largest health site with more than 40 lakh unique visitors per month. We focus on fitness, beauty, health, pregnancy and more.

Most popular health and wellness website in India in 2012 at the Website of the year awards.

health@corp.india.com
+91 – 22 – 6697 1234
Landline Phone number 91 – 22 – 2490 0302.

ZEE ENTERTAINMENT ENTERPRISES LTD, 18th floor, A-Wing, Marathon Futurex, N. M. Joshi Marg, Lower Parel, Mumbai, Maharashtra 400013.

Useful Links

  • Weight Loss
  • Keto Diet Tips
  • Skin Care Tips
  • Intermittent Fasting
  • Apple Cider Vinegar
  • Ashwagandha
  • Cancer
  • Pneumonia
  • Diarrhoea
  • Dengue
  • Typhoid
  • Tuberculosis
  • Chickenpox
  • Chikungunya
  • Depression
  • Hepatitis
  • Diabetes
  • Type 2 diabetes
  • Arthritis
  • Swine Flu
  • Baby Names
  • Cough and cold
  • Heart Attack
  • Breast Cancer
  • Ebola Virus
  • Dengue
  • Malaria
  • International Yoga Day
  • Hypotension
  • Heart Failure
  • Asthma
  • Brain Tumour
  • Celebrity Fitness
  • Goitre
  • HIV/AIDS

We respect your privacy

  • Disclaimer
  • Privacy Policy
  • Contact Us
  • Author Profiles

Copyright © 2021 Zee Entertainment Enterprises Limited. All rights reserved.