Avascular NecrosisAvascular necrosis (AVN), also called osteonecrosis, aseptic necrosis, or ischemic bone necrosis, is a condition that occurs when there is loss of blood to the bone. This is because bone is living tissue that requires blood, an interruption to the blood supply causes bone to die. If not stopped, this process eventually causes the bone to collapse. AVN most commonly occurs in the upper leg. Other common sites are the upper arm, knees, shoulder, and ankles. If AVN left untreated can leads to hip arthritis, which needs surgical intervention like surface replacement or total hip replacement which is a very painful and expensive process.

P D Hinduja Hospital which has been treating patients for 60 years now also completed 10 successful years of research in Avascular Necrosis (AVN) under Dr Sanjay Agarwala.
Dr Agarwala, Chief of Surgery, Head Orthopaedics & Traumatology, Hinduja Hospital has provided a new hope for AVN patients by using the drug Alendronate, bisphosphonate to treat hip AVN. The drug Alendronate prevents bone resorption (which occurs in AVN due to lack of blood supply) and is most commonly and normally used to treat osteoporosis.

Dr Agarwala said, “Avascular Necrosis of the bone is a painful, progressively disabling disorder. The hip (femoral head) is the most common site.  Avascular Necrosis (AVN) of the femoral head is a pathologic process that results from the interruption of blood supply to the bone. Untreated, it progresses to frank hip arthritis needing surgical intervention which is total hip replacement or surface replacement arthroplasty.”

He further added, “The good news for Indian patients is that the cost of this treatment works out to approximately Rs 150 per month and considering that it prevents an expensive 1 lakh surgery and the pain, this is a panacea in the management of these cases.”

In its early stages, AVN is undetectable; however, as the disease progresses it becomes more painful. At first people only experience pain while putting external pressure on the bone. This pain may become more constant. If the disease progresses the bone and surrounding joint collapse, you may experience severe pain that interferes with your ability to use your joint. The time between the first symptoms and collapse of the bone may range from several months to more than a year.

AVN can occur in the people aged between 20 and 50. For healthy people, the risk of AVN is small. Most cases are the result of an underlying health problem or injury.

Possible causes include of AVN include dislocation or fracture of the thigh bone (femur), chronic corticosteroid use, excessive alcohol use, Gaucher’s disease, Sickle cell disease, pancreatitis, HIV infection, radiation therapy or chemotherapy, etc.

  • Ankush Malhotra

    Good morning All
    my name is ankush malhotra and i am 29 yrs old and been treated with AVN. my doctor told me i need a operation . Can some one please advice if surgery is the best option or been treated by medicine

  • singhal

    my wife i suffering from early avascular necrosis AVN in the bilateral femoral head and doctor suggest me to go for surgery but I want to take som alternate medicine pl help me singhal

    • dr sachin a nagrale

      homeopathy can treat all bones who suffered from avn call on this number.9860289238. i can treat without surgery.

  • Chris Scotland

    to all of you don’t take this drug…it swaps one problem for another….go for the surgery….future surgery will be better as our technologies improve….AVN has ruined my life, but the new hip makes it bearable

  • Chris Scotland

    saves the hip and breaks the jaw….I have in my right hip…surgery was fantastic…you will never ever feel the same but you can walk relatively pain free especially compared to how AVN feels at its worst

  • Daniel Christopher McNamara

    Good Day my name is Daniel McNamara I am 34 years old.I have had a kidney transplant when I was 11 years old and been taking prednisone all these years. 5 years post transplant I was diagnosed with large cell lymphoma and had to take chemotherapy for 15 month including radiation therapy. I was diagnosed with AVN last year from all the steroids all these years I have AVN in both hips and now my shoulders. I plan on having surgery in 5 weeks for my right hip and go from there. I am reaally scared my other joints will get just as bad please help me. I would love to learn more about your medicine before the other joints get worse.Please email me at madcuban55@yahoo.com or feel free to call me at 850-527-7728


    Dear Sir,

    I am kadhirvelu.P from namakkal. I am suffering from chronic AVASCULAR NECROSIS beyond third stage in my right hip for the past four years. My age is 39 years. The doctors are advising me to undergo a total hip replacement surgery. The pain is very intense and I could not do my daily activities and unable to walk, sit, stand or climb upstairs in a proper manner.I have undertaken naadi vaithiyam for 6 months but i have no improvement or clarity in treatment. Moreover in siddha treatment i havent got any fine advise with regard to this.So i request you to advise me for my disorder a permanent solution. Awaiting your earnest reply. I am not getting a clearcut idea about AVN. Please advise me

    Thanks and regards,


    • dr sachin a nagrale

      hi kadhirvelu. i understand ur problem. i can treat ur problem without surgery. so please send me all information on this email id.dr.san.clinic@gmail.com

  • Piyush

    I am 25 year old, and having AVN in both femur head. i wanted to know is surgery is the only option for treatment.
    And is the deterioration of bone will stop at any end, or it continues…i can survive with the pain, But scared if it is in progressive manner, its not possible to survive. because I am not capable to afford the expanses of surgery. Please clarify that, is there carcinoma will develop if it is not treated, or any other fatal disease.
    waiting for your reply.

    • dr sachin a nagrale

      hi piyush, i can treat ur avn disease without surgery.if not treated by medicine. deformity can develope. call on this number 9860289238

  • Tunde

    I have a problem with my

  • Bethany

    I’ve been suffering from AVN for almost 11 years now. I got diagnosed when I was 15 and I am now almost 26 years old. I’m in CONSTANT pain of every minuet of everyday. I suffer stage 4 in my right hip, stage 2 in my left hip, stage one in my left shoulder and maybe quite possibly my knees now as well. They hurt just as bad some days. I got diagnosed with leukemia when I was 13 and as a result of the medications I got AVN. It’s put a damper on my life, I used to be heavy into sports, working ect now it hurts just to walk to the bathroom. I can’t even lay Down without pain. I even prop 2 pillows under my right leg so I get some kind of relief. It never used to be this bad, I mean I tolerate the pain my whole life. I don’t even remember what it’s like to walk without pain, that’s a very distant memory. Having this disease in my hips has put a damper on my relationships and I honestly don’t want to do a hip replacement because I’m so young. I take so much arthritise medication I’m afraid it’s killing my organs. So when I ca,e across this article and read some of the testimonies I almost cried because I’m not alone in this. People my age going through and knowing exactly how I feel. My family doesn’t get it they think its SO simple when its not. Who has time and the money to just up and get this big surgery, with extra time to heal ans re learn how to walk? Who has the time to take off work and pay my bills? It’s NOT that simple at all. So if anyone knows the truth to this article and can tell me if itwork, helps ect. Please let me know ASAP because I’m starting to consider surgery for my right hip. I’m scared and honestly was hoping to the hospital surgery part of my life behind. I beat my ALL leukemia and am proud, however I hate that I have to now live with this constant pain aches grinding of my bones day in and out. I will definitely look into this treatment and sincerely mope they find alternative route to cure this awful disease! Thanks so much for taking the time to read my long story. :-)

    • Waqas

      I can understand your feelings my friend i do have the same problem for 5 years my age is 19 only i was a taekwondo player and now i can’t even walk properly sometimes i think that my life is a total waste and i should end it.

    • Surender

      Even i’m also suffering with AVN of my left hip from 12 years.Can you please inform me if u r taking any kind of treatment.

      • dr sachin a nagrale

        call on this number to treat avn without surgery 9860289238